Madikwe Game Reserve lies 90 km north of Zeerust on what used to be farm land, but owing to the poor soil type, farming was not that successful. After extensive research, the South African Government found that this land would best be utilised as a provincial park, to economically uplift this otherwise rather poor area.

The process of reintroducing wildlife to the area began in 1992 under the codename Operation Phoenix which relocated entire breeding herds of elephants, Cape buffaloes, south-central black rhinos and southern white rhinos along with various species of antelopes. Following Operation Phoenix, Madikwe has also successfully reintroduce rarer predatory species such as lions, cheetahs, spotted hyenas and Cape wild dogs bringing the total large mammal population of the reserve to over 10 000. There are currently more than 60 species of mammal in the park.

The reserve has recently opened itself up to private farms outside the main reserve. Private users need to abide by parks board rules, animals can roam over any land, but there are restrictions as to where private vehicles can drive. There are 30 lodges on the property, and six lodges in the private farms outside the main reserve. Some of the commercial lodges include Rhulani Safari Lodge, Jaci’s Lodges, Tau Game Lodge, Etali Safari Lodge, Impodimo Game Lodge and an eco-lodge, Mosetlha Bush Camp. Madikwe has started community lodges, which the local villages own and run. All profits are then used to uplift the communities.