Ganyesa is a town of about 19,000 people in the North West province of South Africa. It is located 70 kilometres (40 mi) north-west of Vryburg and about 170 kilometres (110 mi) south-west of the provincial capital Mafikeng.

It is an administrative centre for the far north-western area of the province, hosting the head offices of the Kagisano-Molopo Local Municipality, a magistrate’s court and various national and provincial government offices.

The census of 2011 recorded the population of the town as 19,290 people, of whom the vast majority were black (98%) and Tswana-speaking (93%).